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Neurosurgery 75 , S24S33 (2014)

2, 3, 4 Thus, increased ROS production, reduced nitric oxide (NO) levels and reduced antioxidant bioavailability were demonstrated in experimental and human hypertension

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Using a coupled assay with Cp1A and Cp1B to form t -ES-l-Ile (vide infra), the stereochemistry of the epoxide formed by Cp1A was assigned to be (2 S ,3 S ) on the basis of a comparison of retention times to those of synthetic (2 S ,3 S )- t -ES-l-Ile ( 14 ) and (2 R ,3 R )- t -ES-l-Ile (Extended Data Fig

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