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The Dug2-Dug3 complex is encoded by two different proteins, Dug2p and Dug3p which combine to make a functional protein complex

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The low pH of acids can destabilize the peptide and reduce effectiveness

484,485 UPS dysregulation in SLE: autoantibodies, antigen processing, and immune signaling In SLE, aberrant UPS activity contributes to inflammatory pathways, defective antigen presentation, and impaired apoptotic processes