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Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

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(1) AOD 9604 peptide appears to exert a weight-reducing potential without altering caloric intake or appetite and without adversely affecting insulin sensitivity

1298A (leading to a Glu at amino acid 429) is the most common while 1298C (leading to an Ala substitution at amino acid 429) is less common