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Conversely, IGF-1 acts to provide an inhibitory feedback signal on GH secretion in the hypothalamus by stimulating somatostatin production in the pituitary [8991]

In addition to this, many people have problems metabolizing B12 in low-quality forms like cyanocobalamin due to defects in the MTHFR gene (1) (as many as 40% of people have THIS problem!)

This dual action, both structural repair and cell replacement, makes P21 one of the most complete neuroregenerative peptides currently under investigation

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FDA Technical Document

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