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Variations in BDNF genotype (compare Intracellular sorting of BDNF in neurons section) are considered to be covariate information in such approaches (Shen et al

Expression of the biosynthetic enzyme for cysteine, cystathionine -lyase (CSE) is drastically decreased in HD due to the sequestration of its transcription factor, specificity protein1 (SP1) by mHtt

Vasina et al., 2009

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Zhao K, So HC (2019) Drug repositioning for schizophrenia and depression/anxiety disorders: a machine learning approach leveraging expression data

For example, drug candidates that act as electrophiles and react with Keap1 thiol groups could act on other electrophile-sensitive pathways, such as histone deacetylase enzymes