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There is evidence that in ovarian cancer, the enzyme indoleamine 2,3-dioxygenase (IDO) catalyzes the breakdown of tryptophan through the kynurenine pathway, resulting in immunosuppressive compounds that accelerate the growth of tumor cells and reduce antitumor immunity (109, 110)

111 Functionally, astrocytes derived from stem cells obtained from ASD patients and grafted into the rodent brain generated abnormal Ca 2+ signals, which are arguably linked to impaired long-term potentiation and repetitive behaviours

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Therapeutic regimens tailored to each patients genetic background, immune status, and gut microbial signature are expected to enhance efficacy while minimizing adverse effects and treatment burden

Crucially, these pathways are fueled by specific dietary risk factors