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Non-oxidizable groups, such as CF3 or tert-butyl, at C3 or C7 improve metabolic stability, as demonstrated in mouse liver microsomes (Farmer et al., 2022)

Quinlan-Davidson SR, Morrison WH, Myers JN, Gunn GB, William WN, Beadle BM, Skinner HD, Gillenwater AM, Frank SJ, Phan J, Johnson FM, Fuller CD, Zafereo ME , Rosenthal DI, Garden AS

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Dietary zinc intake and brain cancer in adults: a case-control study

At high or bolus concentrations, typically achieved with therapeutic NO-donors, NO strongly promotes ferroptosis through several interconnected mechanisms