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The standard protocol includes: 1200 mg to 2400 mg per session, depending on the individuals body weight and skin tone Sessions are typically administered once or twice per week It can take 10-20 sessions of a complete whitening treatment, and then it is necessary to go every month

For survival analysis, AKP tumour-bearing mice were generated as above, and 26 days after induction, they were treated with 150 mg kg 1 5FU (i.p.) 250 mg kg 1 metformin (o.g.) three times weekly

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In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]