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Jacobson MD, Raff MC

Saunders Company

It is therefore to be understood that numerous modifications may be made to the illustrative embodiments and that other arrangements may be devised without departing from the spirit and scope of the present invention as defined by the appended claims

doi: 10.1146/annurev-cellbio-100913-013325 154 ItohN.ItohY.TassoniA.RenE.KaitoM.OhnoA.et al

Top right : Defective RyR1 channels remain open, resulting in excessive Ca release from the SR into the cytoplasm and loss of intracellular calcium homeostasis