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ScienceDirect (2024)

In Keap1 knockdown ( Keap1 KD ) mice, the Keap1 mRNA level is reduced to approximately 5% of that in wild-type mice, and constitutive Nrf2 activation is observed in various tissues, such as liver, lung, and kidney

Research published in the Journal of Biological Chemistry demonstrates that this tripeptide increases fibroblast activity, accelerates keratinocyte proliferation, and enhances the skin's natural regeneration cycle

In conclusion, non-pharmacological therapies that focus on controlling the etiology of liver disease, improving nutrition, increasing muscle mass, mitigating triggers and risk factors, and enhancing coping mechanisms are significantly more effective in combating fatigue in cirrhosis compared to pharmacological treatments (Figure 2) (4, 9)