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We found that DC661 treatment did not increase the expression of MHC class I and immunoproteasome upregulation (Figure 7E and Supplemental Figure 9, B and C)

On the other hand, GPX3 deficiency up-regulated autophagy-related ferroptosis via AMPK/mTOR pathway, and restrained Nrf2/GPX4 levels

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biomedical research can elucidate the molecular mechanisms of action of the active ingredients and their targets

In order to better understand which pathways have the greatest impact on the system in control compared to RP retinas during the first 28 days of postnatal development, we use the GSA method PRCC to investigate the importance of model parameters and initial conditions in relation to the [GSH]/[GSSG] ratio, which reflects antioxidant capacity, as well as in relation to the concentrations of NADPH, ROS and G6P