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gradual dose escalation helps minimize these effects [1][3]

Febuxostat is approved by the FDA to start at 40mg daily, and if the uric acid has not reached goal (less than 6.0mg/dL) after two weeks of treatment the dose can be increased to 80mg daily

Side effects with collagen may include an allergic reaction, digestive issues, hormonal imbalances, and cardiovascular effects

a two-way ANOVA with repeated measures indicated that all time points for the I nmol dihexa group were different from the scopolamine group, which received vehicle (aCSF) instead of dihexa (***p .001)