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Iron Homeostasis and Ferroptosis Susceptibility in Alzheimers and Parkinsons Disease Iron dyshomeostasis is increasingly recognized as a significant contributor to AD pathogenesis, with multiple lines of evidence showing disrupted iron regulation in affected brain regions, particularly those crucial for memory and cognition [111]

Inulin nanoparticles can encapsulate bioactive molecules such as quercetin, improving stability and bioavailability [90]

Notably, patients with mutations in GGT1 often present with developmental disorders, accumulation of GSH (glutathionaemia and glutathionuria) and reduced circulating levels of cystine 25

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Results Phenotypes of MC4R-deficient mice MC4R KO mice showed a significant increase in body weight, food intake, fat mass, and lean mass compared with those in normal mice

590 The expression of PARPs in the injured kidneys proximal tubules is upregulated from 612 h after I/R injury