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Additionally, Hcy induces the expression and secretion of IL-8 by aortic endothelial cells and stimulates MCP-1 production by vascular smooth muscle cells (215, 216)

Poor technique, like vigorous shaking, using the wrong solvent, or ignoring sterility, can cause foaming (which risks oxidation), precipitation (insoluble aggregates), or rapid degradation from bacterial byproducts

Finally, a multicenter randomized controlled trial in China (NCT05690906) is currently recruiting to evaluate a 10 mL PEG hydrogel injection versus no injection in cervical cancer patients undergoing concurrent chemo-radiotherapy and imageguided brachytherapy