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In these patients, treatment with the diuretic agent furosemide decreases serum IGF-1 concentration and normalizes mineral parameters, but did not further increase urinary calcium excretion, suggesting that these effects are mediated by IGF-1.114 Another factor that reduces IGF-1 levels is metabolic acidosis that often may accompany CKD,115 highlighting the complexity of the IGF-1 regulation

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Moreover, VIP has demonstrated neuroprotective effects in neurodegenerative disorders, making it a potential therapeutic target for neuroprotection and neuroregeneration (Delgado et al., 2002)

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