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There are several non-PH-dependent mechanisms by which PPIs affect the intestinal microbiota

These findings align with global analyses from Europe, North America, and Asia reporting similar population-level increases in vitamin B12 deficiency, where prevalence ranges from 5 to 20% depending on age, diet, and socioeconomic status

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Aggregated amylin loses receptor binding capacity and can form cytotoxic assemblies that confound assay results

Excessive copper peptide concentration can potentially shift the collagen synthesis-breakdown balance unfavorably

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