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Associated datasets are provided in Supplementary Tables 14 and 68

Nonalcoholic fatty liver disease (NAFLD), one such pathology, is characterized by abnormally increased fat synthesis and subsequent fat accumulation in hepatocytes 1,2

Studies in people have compared oral SAMe with nonsteroidal anti-inflammatory drugs (NSAIDs

CLINICAL RESULTS 100% showed significant improvement in skin hydration immediately after application* 97% showed a significant reduction in dark spots** 93% showed significant improvement in skin elasticity** 90% showed significant improvement in skin radiance** CONSUMER RESULTS 96% agreed it does not cause any visible signs of irritation or discomfort 91% agreed skin looks and feels less fragile 89% agreed skin elasticity is improved 84% agreed it improves skin density *In a clinical study of 32 women

[16] Only small amounts of choline are synthesized by the human body, necessitating its intake from external sources

*Correspondence: Limei Chen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers