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In fibromyalgia, oxidative stress has also been linked to pathophysiology (Cordero et al., 2010) with studies suggesting that antioxidant therapies may help reduce elevated pro-oxidative pathways such as lipid peroxidation and mitophagy (Assavarittirong et al., 2017) with melatonin being shown to improve brain function in the GWS model, through modulation of oxidative stress (Madhu et al., 2021)

This phenomenon, proposed to occur through enhanced uptake of non-ferritin-bound iron and decreased iron elimination, leads to higher cellular iron concentrations

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