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Abstract: The thymus plays a central role in the development and maintenance of immunity and tolerance, as it provides the microenvironment for T-cell maturation and selection.' The intrathymic differentiation results mainly from cell-to-cell interactions between T-cell precursors and accessory (epithelial and dendritic) cells

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AICAR AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside analog classified as an AMPK activator, available as a lyophilized powder for laboratory research