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The LD50 concept shows how toxicity is measured in preclinical work

doi: 10.1016/j.maturitas.2018.06.010 646 WatanabeT.OdaK.SuzukiY

These results indicate that the P53-P21 axis can negatively regulate the occurrence of ferroptosis in cancer cells

Trends Pharmacol Sci 26(10):517525

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Azimi A

It also results in increased weight gain in women [81] and rodents [82], likely due to androgen-induced leptin insensitivity [82] and impaired insulin-stimulated glucose uptake and lipid metabolism [78, 83]