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Randomised, controlled, doubleblind study of combination therapy of oral tranexamic acid and topical hydroquinone in the treatment of melasma

In fact, they compete for the same coregulators, such as PGC1 and GRIP-1, and genes also compete for shared local enhancers, so that the activation of one gene may repress another that relies on the same enhancers (83)

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Several research teams have targeted GSH synthesis inhibitors as potential therapeutic agents

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Clinical studies have shown no major side effects, though mild bloating or nausea can occur if taken on a very full stomach