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In a study using ApoE -/- mice, TTM treatment for 10 weeks significantly reduced aortic lesion development, indicating its potential as an anti-atherosclerotic agent [139]

All described studies evaluating small intestinal permeability used a 5 or 6 h urinary collection to assess small intestinal permeability, which may have confounded the results since a large amount of the sugars were probably already localized in the colon by the end of the urine collection ( 51 Cr-EDTA in a 24 h urine collection in biopsy proven MAFLD vs

These findings may indicate an infection or other complication requiring medical evaluation

The multidisciplinary approach to acute necrotizing pancreatitis

Hence, only metabolomic studies will help to find out which metabolic pathways are being influenced by givosiran treatment [28]

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