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Step 3 Pigment-signal disruption: Tranexamic Acid blocks the specific cell-signalling pathway responsible for triggering excess melanin production, particularly relevant for stubborn or hormonally-influenced pigmentation

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The acetyl bond is placed on its thiol group or sulfur group, which prevents oxidation and allows the molecule to pass diffusively into the cell after absorption in the gut

This aligns with earlier findings that thrombin is a critical therapeutic target for non-small-cell lung cancer, where its inhibition disrupts the formation of vasculogenic mimicry, a mechanism by which aggressive tumors form fluid-conducting channels independent of ECs [265]

Indeed, GSH covalently binds to some drug molecules in a GST-dependent manner leading to their cellular export and quenches reactive oxidative species often requiring for these compounds to act [27, 28]

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