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Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells

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It particularly inhibits MurA by forming a covalent adduct with a cysteine residue in the active site (Moraes et al., 2015)

When lateral roots are produced, the quiescent center is formed after the appearance of the lateral root from the main root

Crocetin is a naturally occurring dicarboxylic acid apocarotenoid that exhibits a chemopreventive effect on glioblastoma cells by inhibiting proliferation and inducing morphology changes that is mainly mediated through activation of neuronal markers (class III -tubulin and neurofilament) and suppression of mesenchymal markers (cluster of differentiation 44/90, octamer-binding transcription factor 3/4, and C-X-C chemokine receptor type 4) in glioma cells

The reduced form is the active state that is able to neutralize free radicals in the body