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Adequate B12 levels are essential for cognitive function, cardiovascular health, and overall metabolic efficiency

When you lack cobalamin in your diet, it can lead to a range of neurological, physical, and psychological issues, with fatigue being only one symptom

Nevertheless, changes in the endothelial compartment caused by Tbx1 mutation could affect brain metabolism by altering signals or metabolite exchange across cell membranes, which could in turn cause or contribute to the diffuse brain phenotypes observed in Tbx1 +/ mice

Surgery is rare in the management of this condition and only indicated in situations where severe symptoms persist despite extensive conservative treatment

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