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In the study by Neelakantan et al

For instance, when taking Berberine with other cholesterol-lowering agents like red yeast rice, starting with lower doses can help prevent excessive lowering of cholesterol levels

Excess intracellular iron catalyzes Fenton reactions, generating reactive oxygen species (ROS) that oxidize polyunsaturated fatty acids (PUFAs) in membranes [88], resulting in membrane rupture and cell death (Fig