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Of note, agarose control beads (lacking conjugated ubiquitin-associated domains [UBAs]) demonstrated the specificity of this approach, as they failed to purify the ubiquitylated proteome and any inflammasome component (Fig

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Factors such as age, diet, and environmental stressors can influence glutathione levels, but there are effective strategies to enhance its production, including consuming sulfur-rich foods, increasing vitamin C intake, and regular exercise

CGF166, the partners lead candidate, uses an adenovirus carrying the human atonal gene to convert supporting sensory cells into hair cells that, when administered to inner ears of mice, enabled partial recovery of hearing