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For example, calcium deficiency has been reported as possibly associated with an increased risk of colorectal or breast cancer ( The relationship between vitamin and mineral supplementation and cancer is still a highly debated topic, considering the widespread use of various supplements and the often-conflicting results reported in the literature ( In this review, we comprehensively discuss the biology and physiology of vitamins and minerals with a specific focus on cancer (Tables 14), aiming to highlight their potential role in cancer prevention based on the available evidence, while also emphasizing the importance of addressing deficiencies during oncologic treatment by providing a practical overview to facilitate their recognition and management

This changes many cell processes, including how mitochondria function and how cells defend against damage

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Polyphenols may have detrimental effects on the digestive systems function by impacting the composition of the intestinal flora and inhibiting digestive enzymes (602)

Dietary intake of Sulforaphane-rich broccoli sprout extracts during juvenile and adolescence can prevent phencyclidine-induced cognitive deficits at adulthood

Importantly, microglial cells can both produce and be activated by inflammatory cytokines like IL-6, TNF- and IL-1 (also produced by inflammatory monocytes) (171)