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For AL, this includes slow dissolution after injection, enzymatic cleavage by esterases followed by hydrolysis to yield active aripiprazole, and elimination via cytochrome P450 enzymes in the liver.Reference Hard, Mills, Sadler, Turncliff and Citrome 17 Clinicians or patients unfamiliar with the use of LAIs might misconstrue the regimen with greater milligram per injection as necessarily representing a higher dose producing greater plasma concentrations

doi:10.1016/S0021-9258(17)45272-0

Burlingame | Westermeier, Trailing the Cowboy: His Life and Lore as Told by Frontier Journalists, reviewed by Maurice Frink | Beebe and Clegg, The American West

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