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MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a short peptide naturally produced by mitochondria

Proc Natl Acad Sci USA 97(10):51295134

Digestive problems: These can include acid reflux, difficulty swallowing and trouble absorbing vitamins and minerals

Mutations in the DLG motif disrupt the low-affinity binding of Keap1 with Nrf2, resulting in the stabilization of Nrf2, although the association between Keap1 and Nrf2 through the high-affinity binding site, ETGE, is retained