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In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)

Proton magnetic resonance spectroscopy studies have demonstrated a significantly higher Gln/Glu ratio in the anterior cingulate cortex and parieto-occipital cortices of patients with bipolar disorders in maniac episodes compared to healthy subjects (ngr et al., 2008)

Andreeff M , Zhao S, Xie Z, Konopleva M, Estey E, Munsell M, Sanchez-Williams G, Kornblau S, Reed J

Eine ausreichende Zufuhr dieser Vitamine und Mineralstoffe kann durch eine ausgewogene Ernhrung sichergestellt werden

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For example, autophagy is inhibited by the cIII inhibitors Antimycin A or myxothiazol (Vogel et al., 2007), found as a parkin substrate and co-localized with LC3B in CCCP-treated macrophages ( via a similar mechanism in the nervous system