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Moreover, iron is part of the prosthetic group of catalases, key antioxidant enzymes that counteract oxidative stress by catalyzing the reduction and detoxification of hydrogen peroxide

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[11] In practice, this means that while normal doses are safe, any use of pyridoxine beyond typical supplemental levels during pregnancy should be guided by a healthcare providers assessment of risk versus benefit

Similarly, avicularin enhances cognition by modulating NOX4/NRF2 signaling (111) and artemisinin derivatives increase NRF2 activity by targeting its inhibitor kelch-like ECH-associated protein 1 (Keap1) (112)

Wilson and Piel, 2013