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ICP-MS analysis revealed extremely low residual levels of the element Ru in the major organs of rats in the Ru SA+AC group (Fig

Biochemical variables Initial and final biochemical parameters and the evolution after 3 days in patients with septic shock are shown in Table 2

Therefore, we proposed that CTX-induced POI might not be directly related to the apoptosis or oxidative stress of GCs, but rather that it was caused by the accumulation of ferrous ions in GCs mediated by HO-1, which subsequently triggers ferroptosis

PMID: 37 ToledoMMartnez-MartnezSVan HulMLaudoBEyreEPelicaenRet al

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When its function is compromised, it activates the Unfolded Protein Response (UPR) to reestablish normal endoplasmic reticulum activity.Nonetheless, if the stress persists or is excessively severe, and UPR does not successfully reestablish homeostasis, the cell might initiate apoptosis or other forms of programmed cell death ( ERS has a significant connection with ferroptosis