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A major topic in our research group is the role sex hormones play in the risk of Alzheimer's disease and how sex hormones can affect the disease profile

With cuprizone exposure, the recruitment of T-cells to the lesion site [70] may result from the decreased BBB integrity induced by cuprizone [75, 76] Cuprizone toxicity produces profound demyelination in the white and grey matter of the brain that mirrors sites of MS pathology [46]

Spine Res

10.1016/j.lfs.2021.119349 9 AndradeR

That is not a reason to dismiss the animal data, but it is a reason to frame it correctly

As an antioxidant naturally present in our bodies, glutathione plays a crucial role in maintaining cellular health by combating free radicals