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These mechanisms raise a theoretical concern: could supratherapeutic doses accelerate unwanted vascular growth or disrupt dopamine signaling enough to produce neuropsychiatric symptoms

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Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, et al

The fragment appeared to act through a mechanism distinct from the growth hormone receptor, suggesting a favorable safety profile compared to full-length GH [2]