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Wesley-Smith, L

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No restrictions were placed on study design, enabling the inclusion of in vitro, in vivo, clinical studies, and systematic or narrative reviews

He hypothesized that lactic acidosis, increased concentration of Krebs cycle metabolites in urine, reduced levels of carnitine in plasma, decreased utilization of glucose in the brain, and lowered ATP levels in these patients are associated with mitochondrial dysfunction [66]

Whether you are on a starting dose of 2.5mg or working up to 10mg per week, the amount of water you add to that vial determines how easy or difficult accurate dosing becomes

Addressing these limitations requires rigorous study design with adequately powered cohorts, clearly documented randomization and blinding, and standardized CP and protective agent dosing paradigms