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Gene expression modulation

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These findings are consistent with the fact that in patients with silicosis, overexpressed lncRNA-ATB can interact with miR-200c and target ZEB1 expression upregulation, thus driving EMT occurrence (70,96)

Conversely, if recruited during inflammation, monocytes will exhibit a pro-inflammatory phenotype and produce pro-inflammatory cytokines, commonly referred to as M1 macrophages (classically activated) [88,89,90]

Conclusions and Future Perspectives BACH1 is associated with oxidative stress responses, and it regulates the antioxidant defense system by controlling the expression of genes associated with ROS metabolism