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Ultimately, achieving gut homeostasis in AS will demand an integrated strategy that simultaneously modifies diet, rebalances the microbiota, and restores the intestinal barrier to extinguish the upstream triggers of articular inflammation

Specifically, we found that GSSG elevation suppressed the phosphorylation/activation of IKK-, a proximal kinase in the NF-B signaling pathway that phosphorylates IB-, leading to its proteasomal degradation and subsequent NF-B activation

Levin R, Villanueva CM, Beene D, et al

However, the translational gap between the in vitro efficacy and the in vivo performance of many bioactive compounds (BACs) remains a major bottleneck in the development of efficacious nutraceutical products (1, 2)

This most likely reflects the potential toxicity of this compound in relatively high levels, observed under in vitro and in vivo conditions (Yang et al., 2000