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Nicotinamide is a form of vitamin B3 used in dermatology for its promising effects on preventing skin aging and cancers caused by sun exposure

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It can influence pro-inflammatory molecules like interleukin-6 (IL-6) and TNF-alpha, which are linked to prolonged inflammation in injury models

Among the 8 identified metabolites, the levels of L-acetylcarnitine, L-carnitine, ribonic acid, and glucaric acid tended to increase from stage 1 and became significantly higher in stage 3 when compared to controls (Fig

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