paracetamol overdose glutathione depletion metabolism Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Ferroptosis and intrinsic drug induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective EurekAlert! Full article: Paracetamol: overdose induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro Acetaminophen Toxicity Explained Stages, Diagnosis & N Acetylcysteine Treatment CanadaQBank Acetaminophen (Paracetamol) Poisoning RECAPEM Acetaminophen, ethanol and other co ingestions ScienceDirect
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