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Blood flow responses to deep brain stimulation of thalamus

Liraglutide, semaglutide and tirzepatide are incretin-based therapies currently approved by FDA for the management of obesity, while triple GIPR/GCGR/GLP-1R agonist retatrutide (LY3437943), the cagrilintide/semaglutide (CagriSema) 2.4 mg combination, high-dose oral semaglutide, and oral orforglipron are in advanced stages of development

The full course of treatment varies but typically runs six months to one year before evaluating maintenance strategies

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Significantly, the RSM does not impose a singular or universal ordering