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10 mM), an ATP synthase inhibitor

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doi: 10.1158/0008-5472.CAN-11-3919 228 PandaAMehnertJMHirshfieldKMRiedlingerGDamareSSaundersTet al

It is estimated that approximately 10% of the human proteome binds zinc, with zinc finger transcription factors alone accounting for hundreds of proteins that regulate DNA expression and repair 11,12

Here, we examine studies that have combined molecular and behavioural approaches in rodents to elucidate the molecular mechanisms that keep the social intake of alcohol in check, which we term 'stop pathways', and the neuroadaptations that underlie the transition from moderate to uncontrolled, excessive alcohol intake, which we term 'go pathways'

The N-terminal domain contains the activation function 1 domain (AF-1) that recruits co-regulators in a ligand-independent manner, while the ligand-binding domain contains a second transactivation domain (AF-2) that serves as a platform for a different set of ligand-dependent coregulators (20, 21)