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It is also likely the SM-HLCs have alterations in metabolic gene expression with resultant changes of TCA cycle/glycolytic/mitochondrial intermediates that are geared towards high proliferation, high plasticity and dedifferentiation

Furthermore, peptides typically exhibit poor membrane permeability [121]

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This discrepancy may stem from differences in study populations, and both studies are limited by small sample sizes, making it difficult to exclude confounding effects of baseline microbiota composition, disease duration, and intervention duration

Researchers often use it in short courses targeted at specific infectious or dysbiotic contributions to autoimmune activation, rather than as a long-term immune-modulating agent

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