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STAT5b is of most importance and directly regulates the expression of IGF-1 (43, 44), and was demonstrated to be a mediator of GH-induced IGF-1 production in rat granulosa cells (Figure 2) (33, 45, 46)

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In another, a lifespan trial in Swiss-derived SHR mice (1 g/mouse per month) reported no changes in food intake or body weight, while chromosomal aberrations decreased and maximum lifespan increased [7]

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