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Previous studies have shown hypoperfusion and reduction in the biosynthesis of neurotransmitters such as gamma aminobutyric acid (GABA), glutamate, and aspartate in the frontal, occipital, cingulate, and temporal cortices and basal ganglia

Such preparations are of great importance because they improve muscular activity, thereby increasing endurance and stress tolerance, as well as delayed fatigue and shorter recovery times

Propionate infused rats are an appropriate animal model of autism not only because of their very similar behaviour to autistic childrens but also because of their similar biochemical profiles [30]

A change in the regulation of Ca 2+ in lymphocytes disrupts the control of metabolism, proliferation, differentiation, secretion of antibodies, cytokines and cytotoxicity, which leads to autoimmune and inflammation diseases (130)