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Gnoni A, Longo S, Gnoni GV et al

In case of unsatisfactory clinical response, the dose can be increased to 1000g [447-449]

Both excessively high and excessively low levels of autophagy can exacerbate hepatocyte injury

That is exactly the bottleneck that generative models, structure prediction, and ADMET (absorption, distribution, metabolism, excretion, toxicity) prediction are built to widen