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Annu Rev Nutr 20:663697

In the process of neutralizing free radicals, antioxidants themselves become oxidized

Kim JH, Kim WS, Yun Y, Park C

Reactive oxygen species-responsive nanoplatforms for nucleic acid-based gene therapy of cancer and inflammatory diseases

doi: 10.1016/j.neuropharm.2024.109929, 22

The key mutation involves the oxidative modification of guanine to form 8-oxoguanine (8-oxo-G) in DNA, termed 8-oxo-7-hydro2-deoxyguanosine (8-oxo-dG) (see Fig