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doi: 10.1016/j.cell.2013.12.010 [DOI] [PMC free article] [PubMed] [Google Scholar] 17.Yu H, Guo P, Xie X, Wang Y, Chen G

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Step 2: Add Targeted Anti-Inflammatory and Antioxidant Support Once a foundation is in placeor if inflammation and pain remain prominentadditional support may be layered in based on symptoms: Turmeric (curcumin) to further downregulate inflammatory pathways and immune activation Adaptogens (such as those found in Adrenal Support) to improve stress resilience, support cortisol regulation, and reduce stress-triggered symptom flares Additional antioxidants if labs or symptoms suggest elevated oxidative stress These supplements are best added gradually, allowing time to assess tolerance and symptom response

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However, on the flip side, as the glycosuric impact of SGLT2 inhibitors diminishes beyond stage 3 CKD, concerns regarding EKA are unlikely to be applicable to the PD population