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Campbell JD, et al

in the absence of normal gut microbiota in the mouse dams, the expression of BEC claudin-5 and occludin is diminished and an increase in BBB permeability is observed in the offspring (Welcome, 2019)

IGF-I is involved in neuronal myoblast proliferation and differentiation, and organ development

FIGURE 2 TIRAP (toll/interleukin-1 receptor domain-containing adapter protein) recruits MyD88 (myeloid differentiation factor 88) directly to the TLR4 cytoplasmic domain

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Statins broader effects, including their ability to reduce systemic inflammation and biomarkers associated with poor ICI response (such as IL-6 and C-reactive protein [CRP]), further complicate the picture