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In summary, these data provide evidence that long-term IGF-1R blockade with mAbs is feasible, well tolerated, and can recapitulate effects observed with genetic disruption of IGF-1R signaling on lifespan

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Current investigations continue to assess how peptide-based compounds interact within multi-pathway signaling environments, including potential influences on coordinated cellular processes and system-level biological responses in controlled laboratory models

Many patients continue to make progress with therapy